- Meathook – Since Prince Arthas first encountered the Scourge abominations, they have become even more menacing. Meathook has grown stronger, more toxic and more agile than the others. Smarter was never the goal of the necromancers who created Meathook, but it only takes a base cunning to do what he does best.
- Salramm the Fleshcrafter – Salramm the Fleshcrafter was one of the first necromancers trained in the halls beneath Scholomance. He saw the test subjects, and occasional fellow students, as little more than a collection of interesting parts for his work. Now he has the entire population of Stratholme for his experiments... along with any interlopers who try to stop him.
- Chrono-Lord Epoch – The infinite dragonflight often tries subtle methods to manipulate the timeways, but if that fails they can send an assassin to deal with Arthas directly. While little is known about the agents of the infinite dragonflight, Epoch displays a dangerous mastery of time that makes him a deadly obstacle to Arthas's future.
- Mal'Ganis – The destiny of Mal'Ganis has already been written. Arthas's hatred for the dreadlord will cause the prince to travel to Northrend and take up Frostmourne. But this will only happen if Mal'Ganis finds him worthy. To prove his worthiness and begin down his path to becoming the Lich King, Arthas must survive Mal'Ganis's onslaught.